Custom Enzymes and Inhibitors
Selleck Chemical LLC Aurora A Inhibitor I (TC-S 7010) 50mg 1158838-45-9
Aurora A Inhibitor I (TC-S 7010) is a novel, potent, and selective inhibitor of Aurora A with IC50 of 3.4 nM in a cell-free assay. It is 1000-fold more selective for Aurora A than Aurora B. Aurora A Inhibitor I (TC-S 7010) triggers apoptosis through the ROS-mediated UPR signaling pathway. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Ace Glass, Inc. 125mL GL25 top #25 bottom peptide vessel body, 2mm bore PTFE stopcock side port
125ML GL25 NO.25 PEPT BODY
Ace Glass, Inc. 500mL GL32 top #50 bottom peptide vessel body, 2mm bore PTFE stopcock side port
500ML GL32 NO.50 PEPT BODY
Ace Glass, Inc. 20mL GL14 top #15 bottom peptide vessel body, 2mm bore PTFE stopcock side port.
20ML GL14 NO.15 PEPT BODY
Apexbio Technology LLC ICG 001, 847591-62-2, MFCD12196918, 5 mg
MF: C33H32N4O4, MW: 548.63, Solubility: 27.4315mg/mL in DMSO, 35.47 mg/mL in EtOH with ultrasonic,insoluble in H2O. ICG001 is a small molecule inhibitor that targets Wnt/beta-catenin pathway. It inhibits TCF/beta-catenin mediated transcription by competing with beta-catenin for CBP (CREB binding protein) but not p300 binding with an IC50 of 3 uM. It can be used to specifically evaluate the role of CBP/beta-catenin association on WNT signaling and cell physiology.
Apexbio Technology LLC ICG 001, 10mg. Cas: 847591-62-2 MFCD: MFCD12196918. Wnt/β-catenin pathway inhibitor
Wnt/ Beta -catenin pathway inhibitor blocking Beta -catenin/CBP interaction 847591-62-2. MFCD12196918
Selleck Chemical LLC PD153035 HCl 10mg 183322-45-4 SU-5271 (AG1517) HCl ,ZM 252868 HCl
PD153035 HCl (SU-5271 HCl, AG1517 HCl, ZM 252868 HCl) is a potent and specific inhibitor of EGFR with Ki and IC50 of 5.2 pM and 29 pM in cell-free assays; little effect noted against PGDFR, FGFR, CSF-1, InsR and Src. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Lapatinib (GW-572016) Ditosylate 100mg 388082-77-7
Lapatinib (GW-572016) Ditosylate is a potent EGFR and ErbB2 inhibitor with IC50 of 10.8 and 9.2 nM in cell-free assays, respectively. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC YM155 (Sepantronium Bromide) 100mg 781661-94-7
YM155 (Sepantronium Bromide) is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM in HeLa-SURP-luc and CHO-SV40-luc cells; does not significantly inhibit SV40 promoter activity, but is observed to slightly inhibit the interaction of Survivin with XIAP. YM155 down-regulates survivin and XIAP, modulates autophagy and induces autophagy-dependent DNA damage in breast cancer cells. Phase 2. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC Quizartinib (AC220) 50mg 950769-58-1
Quizartinib (AC220) is a second-generation FLT3 inhibitor for Flt3(ITD/WT) with IC50 of 1.1 nM/4.2 nM in MV4-11 and RS4;11 cells, respectively, 10-fold more selective for Flt3 than KIT, PDGFR?, PDGFR?, RET, and CSF-1R. Quizartinib (AC220) induces apoptosis of tumor cells. Phase 3. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC OSU-03012 (AR-12) 5mg 742112-33-0
OSU-03012 (AR-12) is a potent inhibitor of recombinant PDK-1(phosphoinositide-dependent kinase 1) with IC50 of 5 ?M in a cell-free assay and 2-fold increase in potency over OSU-02067. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC PF-04217903 50mg 956905-27-4
PF-04217903 is a selective ATP-competitive c-Met inhibitor with IC50 of 4.8 nM in A549 cell line, susceptible to oncogenic mutations (no activity to Y1230C mutant). Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Selleck Chemical LLC SNS-032 (BMS-387032) 50mg 345627-80-7
SNS-032 (BMS-387032) has firstly been described as a selective inhibitor of CDK2 with IC50 of 48 nM in cell-free assays and is 10- and 20-fold selective over CDK1/CDK4. It is also found to be sensitive to CDK7/9 with IC50 of 62 nM/4 nM, with little effect on CDK6. SNS-032 (BMS-387032) induces apoptosis. Phase 1. *For Research & Development use only. Product is not intended for drug, household, or human consumption.
Sigma Aldrich Fine Chemicals Biosciences 4-Quinolinol 98% | 611-36-9 | MFCD00006777 | 5G
4-Quinolinol 98% | Purity: 98% | Mol Wt: 145.16 | 611-36-9 | MFCD00006777 | 5G
